JavaScript is off. Please enable to view full site.

WHO to consider adding obesity drugs to 'essential' medicines list

WHO to consider adding obesity drugs to 'essential' medicines list

Wednesday, March 29, 2023, 14:40 GMT+7
WHO to consider adding obesity drugs to 'essential' medicines list
A player is pictured during his "Futbol de Peso" (Soccer of Weight ) league soccer match, a league for obese men who want to improve their health through soccer and nutritional counseling, in San Nicolas de los Garza, Mexico, September 16, 2017. Photo: Reuters

Drugs that combat obesity could for the first time be included on the World Health Organization's "essential medicines list," used to guide government purchasing decisions in low- and middle-income countries, the U.N. agency told Reuters.

A panel of advisers to the WHO will review new requests for drugs to be included next month, with an updated essential medicines list due in September.

The request to consider obesity drugs was submitted by three doctors and a researcher in the United States. It covers the active ingredient liraglutide in Novo Nordisk's obesity drug Saxenda, which will come off patent soon, allowing for cheaper generic versions.

The panel could reject the request or wait for more evidence. A decision by the WHO to include Saxenda and eventual generics on the list would mark a new approach to global obesity by the health agency.

It could also pave the way for a newer, more powerful treatment from Novo Nordisk called Wegovy to be recommended for low- and middle-income countries in future.

However, some public health experts warn against introducing such medicines too broadly as a solution to a complex condition that is still not completely understood.

"Obesity is an increasingly important health problem in many countries," said a WHO spokesperson. "Medicines for the treatment of obesity are only one aspect of management, of course, and prevention is also crucial."

The WHO said the expert panel would consider the evidence for liraglutide over the coming months. They may also seek a broader evaluation of other types of weight-loss treatments in the future.

Over 650 million adults worldwide are obese, more than triple the rate in 1975, and roughly another 1.3 billion are overweight, according to the WHO. The majority – 70% - live in low- and middle-income countries.

Expanding access

Including obesity drugs among the WHO's essential medicines could have great significance for that population. Experts say that adding HIV drugs to the list in 2002 helped to make them much more widely available to AIDS patients in poorer countries.

“At present, there are no medications included in the (list) that specifically target weight loss for the ongoing global burden of obesity,” wrote U.S. researcher Dr. Sanjana Garimella from Yale New Haven Health, Dr. Sandeep Kishore from the University of California, San Francisco, and colleagues to the WHO in requesting the addition. They did not respond to Reuters requests for comment.

They argue that while the list includes mineral supplements for nutritional deficiencies, the lack of weight-loss treatments represents a "discrepancy" in global health equity, given the increasing number of deaths in poorer nations hastened by weight-related illness, including heart disease and diabetes.

Saxenda, a once-daily injection, has been shown to help people reduce 5%-10% of their body weight, at $450 per month in the United States and $150 per month in Europe.

People using Wegovy, a weekly injection that costs more than $1,300 a month in the United States, have lost up to 15% of their weight. At the moment, Wegovy is in short supply and Novo is prioritizing its launch and distribution in the U.S. and other wealthy markets.

The Danish drugmaker in a statement said it was not involved in the application to consider liraglutide for inclusion on the WHO list, adding, "we welcome the WHO review and look forward to the readout and decision."

Both drugs belong to a class of medicines called GLP-1 receptor agonists, which have been used for years to treat diabetes. They affect hunger signals to the brain and slow the rate at which a person’s stomach empties, making them feel fuller longer. Eli Lilly and Co (LLY.N) has a similar diabetes drug nearing approval for weight loss.

For both Saxenda and Wegovy, there is a lack of long-term safety and effectiveness data for obesity. Studies suggest people will likely have to take the drugs for the rest of their lives to keep the weight off.

High-income countries are taking varying approaches for how to use these medicines, including contemplating whether they can be prescribed by government-sponsored health systems or covered by insurance, as they are for diabetes. In some countries, their use is being reserved only for the most at-risk groups.

Professor Zulfiqar Bhutta, an obesity expert at the University of Toronto, said the phenomenon of obesity in low- and middle-income countries must be better understood to help determine the best course of action

"Preventive strategies and sustained efforts at education, gender-focused interventions, must take precedence over the use of obesity drugs, which require a lot more research for safety and effectiveness," he said.



Read more

Vaquitas still exist, but barely: sea 'panda' survey

The vaquita, a small porpoise on the verge of extinction, is still hanging in there, said scientists Wednesday who had spotted about a dozen specimens of Mexico's 'panda of the sea' on an expedition in May

2 days ago



‘Taste of Australia’ gala dinner held in Ho Chi Minh City after 2-year hiatus

Taste of Australia Gala Reception has returned to the Park Hyatt Hotel in Ho Chi Minh City's District 1 after a two-year hiatus due to the COVID-19 pandemic

Vietnamese woman gives unconditional love to hundreds of adopted children

Despite her own immense hardship, she has taken in and cared for hundreds of orphans over the past three decades.

Vietnam’s Mekong Delta celebrates spring with ‘hat boi’ performances

The art form is so popular that it attracts people from all ages in the Mekong Delta

Vietnamese youngster travels back in time with clay miniatures

Each work is a scene caught by Dung and kept in his memories through his journeys across Vietnam

Latest news