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AstraZeneca denies report vaccine less effective in elderly

AstraZeneca denies report vaccine less effective in elderly

Tuesday, January 26, 2021, 08:46 GMT+7
AstraZeneca denies report vaccine less effective in elderly
Vials with a sticker reading, "COVID-19 / Coronavirus vaccine / Injection only" and a medical syringe are seen in front of a displayed AstraZeneca logo in this illustration taken October 31, 2020. Photo: Reuters

FRANKFURT -- AstraZeneca denied on Monday its COVID-19 vaccine is not very effective for people over 65, after German media reports said officials fear the vaccine may not be approved in the European Union for use in the elderly.

German daily papers Handelsblatt and Bild said in separate reports the vaccine - co-developed by AstraZeneca and Oxford University - had an efficacy of 8% or less than 10%, respectively, in those over 65.

German officials were concerned that the vaccine may not receive approval from the EU’s medicines authority EMA for use in those over 65, Bild said in its online edition.

The reports mark another potential issue for AstraZeneca, which told the EU on Friday it could not meet agreed supply targets up to the end of March after running into vaccine production problems.

Frustration was already growing among European countries because Pfizer and partner BioNTech announced a temporary slowdown in vaccine supplies earlier in January.

In a written response, AstraZeneca described the German media reports saying its COVID-19 vaccine was shown to have a very low efficacy in the elderly as “completely incorrect”.

It said Britain’s Joint Committee on Vaccination and Immunisation supported the vaccine’s use in the elderly. It also said that a strong immune responses to the vaccine had been shown in blood analysis of elderly trial participants.

Britain on Dec. 30 became the first country to approve the two-shot vaccine and did not impose an upper age limit. It has so far focused on the elderly and healthcare workers for its immunisation campaign.

AstraZeneca’s main trial in Britain started testing on adults no older than 55 because it initially focused on healthcare personnel and frontline workers in active duty.

Elderly trial participants were recruited later so that infections, which are needed to arrive at reliable efficacy data, were also coming in later.

Researchers at Oxford University said in a paper published in medical journal The Lancet on Dec. 8, when details of key vaccine trials held in Britain and Brazil were released, that efficacy data based on infections in the elderly were still limited.

“Efficacy data in these cohorts are currently limited by the small number of (infection) cases, but additional data will be available in future analyses,” they said in the paper.

Reuters

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