The Ministry of Health documented more than 12,000 domestic COVID-19 cases on Wednesday, along with over 7,600 recoveries and 335 fatalities.
Thirty-six provinces and cities logged 12,093 local cases whereas a separate three infections were imported from abroad, the health ministry said.
The health ministry had documented 10,797 locally-infected patients on Tuesday.
More than 7,300 of the latest local cases were found in the community while the remaining were detected in isolated areas or centralized quarantine facilities.
Ho Chi Minh City registered 5,294 of the new domestic infections, up by 667 patients; Binh Duong Province 4,129, up by 501; Dong Nai Province 618; Long An Province 460; Tien Giang Province 319; Da Nang 162; Khanh Hoa Province 150; Tay Ninh Province 119; Binh Thuan Province 106; and Hanoi 96.
Since the fourth COVID-19 wave began in Vietnam on April 27, the country has confirmed 377,245 community transmissions in 62 out of its 63 provinces and cities.
Ho Chi Minh City stays atop with 190,166 patients, followed by Binh Duong Province with 81,182, Dong Nai Province with 19,728, Long An Province with 19,046, Tien Giang Province with 8,155, Dong Thap Province with 6,316, Khanh Hoa Province with 5,862, Bac Giang Province with 5,840, Da Nang with 3,561, and Hanoi with 3,005.
By comparison, Vietnam confirmed 106 community cases in the first wave from January 23 to April 16, 2020, 554 in the second from July 25 to December 1, 2020, and 910 in the third from January 28 to March 25, 2021.
The ministry recorded 7,646 recoveries on Wednesday, bringing the total to 169,921 recovered patients.
The death toll has mounted to 9,349 after the health ministry documented 335 fatalities the same day, including 266 in Ho Chi Minh City and 31 in Binh Duong Province.
The Southeast Asian country has detected an accumulation of 381,363 cases since the COVID-19 pandemic first hit it on January 23, 2020.
Health workers gave 432,460 vaccine doses on Tuesday.
More than 18 million vaccine shots have been administered in Vietnam since the country rolled out vaccination on March 8, with over two million people having been fully vaccinated.
The Vietnamese government expects to obtain 175 million shots of various vaccines, including 51 million Pfizer-BioNTech jabs, by early 2022.
It set a target of immunizing two-thirds of a population of nearly 98 million people against COVID-19 by the first quarter of next year.